Surgical site infections (SSI) are associated with significant patient morbidity and mortality. Efforts to prevent the risk of SSIs requires knowledge of the mechanistic factors responsible for the etiology of these severe healthcare-associated infections (HAI). Therefore, development of a successful patient-centric pathway to improving surgical outcomes requires matching comorbid risk with effective evidence-based interventional strategies.
The cornerstone for this improvement in clinical outcome is the surgical care bundle which is not a static but rather a dynamic process that is subject to change since evidence-based medicine is an evolutionary process. The present discussion will focus on our current understanding of how selective interventional practices (surgical care bundles) when matched with patient comorbid risk can lead to improved clinical outcomes.